FANCJ REGULATES INTERSTRAND CROSSLINKER INDUCED CENTROSOME AMPLIFICATION THROUGH THE ACTIVATION OF POLO-LIKE KINASE 1

FancJ regulates interstrand crosslinker induced centrosome amplification through the activation of polo-like kinase 1

Summary DNA damage response (DDR) and the centrosome cycle are two of the most critical processes for maintaining a stable genome in animals.Sporadic evidence suggests a connection between these two processes.Here, we report our findings that six Fanconi Anemia (FA) proteins, including FancI and FancJ, localize to the centrosome.Intriguingly, we fo

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The USP21/YY1/SNHG16 axis contributes to tumor proliferation, migration, and invasion of non-small-cell lung cancer

Lung cancer: Targeting a vicious circle Therapies targeting a molecular feedback loop involved in tumor growth may prove valuable for Fan Shop - Licensed Baseball - Hats treating non-small-cell lung cancer.Fangbao Ding, Jianbing Huang, and co-workers at Shanghai Jiao Tong University in Shanghai, China, have shown how an enzyme called USP21 promotes

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Anthropogenic impact on intraspecific ecological-temporal differentiation and structure of populations of pacific salmons

Clamps Intraspecific temporal differentiation and population structure should be accounted in fishery, artificial breeding and introduction of anadromous species to provide stability of their ecological and genetic structure and maintain their high abundance.There is TROUSERS JEANS shown for the case of pacific salmons that ignoring of the populati

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Falco: high-speed FastQC emulation for quality control of sequencing data [version 2; peer review: 2 approved]

Quality control is an essential first step in sequencing data analysis, and software tools for quality control are Tamper-Evident Labels deeply entrenched in standard pipelines at most sequencing centers.Although the associated computations are straightforward, in many settings the total computing effort required for quality control TROUSERS JEANS

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